PUCL Job#1136 - Scientist I, Core Lab (Posted June 15, 2017)


Please contact:

Richard Konz
Group Leader / Head
CyTOF, Flow and Image Cytometry Core Facility

EMD Serono A business of Merck KGaA, Darmstadt, Germany

EMD Serono Research and Development Institute, Inc. | 45A Middlesex Turnpike | Billerica, MA 01821 | USA

Office: +1 978-625-5616 | Mobile: +1 978-495-6407 | Email:




Job Title: Scientist I, Core Lab

Req ID 154617 - Posted 06/02/2017United StatesMassachusettsBillericaResearch & Development
(C - Professional (1-3 years))full-time

A career with us is an ongoing journey of discovery: our 50,000 people are shaping how the world lives, works and plays through next generation advancements in healthcare, life science and performance materials. For 350 years and across the world we have passionately pursued our curiosity to find novel and vibrant ways of enhancing the lives of others.


Who we are:

EMD Serono is a North American division of Merck KGaA, Darmstadt, Germany a leading science and technology company in healthcare, life science and performance materials. Around 50,000 employees in 66 countries work to further develop technologies that improve and enhance life – from biopharmaceutical therapies to treat cancer or multiple sclerosis, cutting-edge systems for scientific research and production, to liquid crystals for smartphones and LCD televisions.


At EMD Serono strive to create value and benefit patients by transforming medical science into breakthrough solutions in our core therapeutic areas of neurodegenerative diseases, fertility and metabolic endocrinology, as well as oncology and autoimmune/inflammatory diseases as emerging areas of expertise.





The Core Lab Scientist I is responsible for the theoretical development and technical adjustment of new or existing products. Formulates research programs on the basic products, the technological issues and the use of products and related matters. Conducts continued research of (drug) molecules under development, for their refinement following (drug) discovery and molecular definition. Transforms results of internal or external research activities into designs and specifications of specific products. Develops manufacturing processes for initial supply of materials for laboratory testing.



·       Responsible for ensuring good daily operation of the core laboratory and all associated equipment. Incumbent will be experienced with the operation and maintenance of equipment such as the florescent activated cell sorting (FACS) instruments, flow cytometry equipment and mass cytometry using time of flight mass spectroscopy (CyToF)

·       The majority of time will be spent in the laboratory working with technical equipment and producing data for experiments designed and requested by the translational innovation platforms (TIPs – therapeutic areas). Familiarity with good laboratory documentation, understanding of critical time lines and delivery of timely results is required. Experience with troubleshooting both instrumentation and assays is essential. Specific tasks include:

·       Maintain, calibrate and operate flow cytometry analytical equipment and instruments

·       Develop and qualify robust flow cytometry methods; transfer to contract organizations when needed

·       Develop standard operating procedures, analytical test methods and analytical sampling plans

·       Write, review and edit accurate technical documents

·       Operate in a matrixed environment and work with cross-functional teams

·       Develop process improvements and efficiencies

·       Design and execute experimental approaches and new analytical technologies and assist with the continuous improvement of analytical tools

·       Maintain a current understanding of recent developments in technology and methods and the application of them to SRDI experiments

·       Provide technical leadership to reagent and assay development

·       Responsible for ensuring the training of all users of technical instruments of the Core Lab.

·       Subject matter expert (SME) in flow cytometry, florescent activated cell sorting (FACS) and mass cytometry (CyToF)

·       Contribute to scientific journal publications and internal SOP’s

·       Participation in external publications and professional associations



·       Ensure efficient buying of reagents, antibodies, tags, buffers and other consumables that leverages maximum discounting available.  Also ensure that the equipment service contracts are current and compliant with terms of the contract especially regarding preventative maintenance.



The Core Lab Scientist I incumbent by attending to the calibration/maintenance and documentation of key technical equipment on site, will effectively provide higher performance consistency and data integrity for critical experiments that support priority research programs.  This is an improved process that centralizes technical responsibility to the Core Lab from a process that has technical instrumentation responsibility embedded within the TIPs. Further expansion of lab operations to include Global Early Development (GED) bioanalytical and biomarker wet labs, underscores the utility of this position to ensure compliant documentation, training and instrument performance by a subject matter expert (SME).

Providing this service and expertise will also increase the use of leading edge technology such as CyToF and potentially result in improved program planning and experiments.


This is a highly collaborative and communicative position.  Expected daily communications with internal and external collaborators especially by telephone and email is expected. Face to face communication with scientists from the TIPs, GED and Discovery Technologies is also a daily occurrence. Interactions include the exchange of scientific methods, delivery of technical lab results, development of presentation material and visualizations, and the exchange of technical information from the literature and other sources.




·       M.S. or PhD in applicable discipline required.



·       Requires two to four years direct lab experience.

·       Must be a subject matter expert in some or all of the following technical platforms:

·       Mass cytometry (CyToF)

·       Flow Cytometry

·       Florescent Activated Cell Sorting (FACS)

·       Requires a solid theoretical understanding of immunology and immunological techniques with work experience demonstrating the ability to evaluate and review experimental data, implement quality control measures and deliver the final results in appropriate formats. Experience with operating a core lab facility, training and training development is a plus



·       Collaboration and communication are key competencies for this individual contributor. Specific competencies also include:

·       Assertiveness and independence, ability to self-motivate and work independently

·       Detail oriented, ability to aggregate data and results understanding how raw data support conclusions

·       Strong verbal and written communication skills

·       Excellent record management habits and fundamental understanding of documenting intellectual property.

·       Mechanical aptitude with technical and problem-solving skills

·       Capacity to adapt with strong motivation to learn new concepts and techniques.

·       Proficient in use of technical equipment including CyToF as well as associated software (eg. FlowJo, Prism)



·       Work area is not compatible for service animals

·       Lifting up to 50 pounds may be required

·       Standing at a lab bench required, variable heights

·       Requires computer use and ability to read computer screens


What we offer: With us, there are always opportunities to break new ground. We empower you to fulfil your ambitions, and our diverse businesses offer various career moves to seek new horizons. We trust you with responsibility early on and support you to draw your own career map that is responsive to your aspirations and priorities in life. Join us and bring your curiosity to life!

Curious? Apply and find more information at


The Company is an Equal Employment Opportunity employer. No employee or applicant for employment will be discriminated against on the basis of race, color, religion, age, sex, sexual orientation, national origin, ancestry, disability, military or veteran status, genetic information, gender identity, transgender status, marital status, or any other classification protected by applicable federal, state, or local law.  This policy of Equal Employment Opportunity applies to all policies and programs relating to recruitment and hiring, promotion, compensation, benefits, discipline, termination, and all other terms and conditions of employment. Any applicant or employee who believes they have been discriminated against by the Company or anyone acting on behalf of the Company must report any concerns to his/her Human Resources Business Partner, Legal, or Compliance immediately. The Company will not retaliate against any individual because he/she made a good faith report of discrimination.


EMD Serono is a division of Merck KGaA, Darmstadt Germany.



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